Best Practices for setting up document management with SharePoint

Hi all,

Is there any guidance or best practices on how to organise a document management system that will easily scale up to the hundreds of GBs? We are looking to set up a system where each department has its own library but I am considering scrapping this idea and putting all documents in a single library on a site collection outside the base site collection that users browse to. Once this site collection fills up I can create a second one to easily scale up.

My concern is that with having a library for each department I will not be able to do this easily... any thoughts?

Thanks

Tal